Klinik für Kinderchirurgie 

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Foto zeigt ein großes Holzboot auf der kinderchirurgischen Station.

Forschung in der Klinik für Kinderchirurgie

Die Klinik für Kinderchirurgie beteiligt sich an mehreren Forschungsbereichen mit unterschiedlichen Schwerpunkten.

Sie befinden sich hier:

Forschungsschwerpunkte der Klinik für Kinderchirurgie

  • Anorektale Fehlbildungen
  • Teilnahme an der Cure-Net Studie
  • M. Hirschsprung
  • Inkontinenz
  • Appendizitis
  • Akutes Abdomen bei extrem untergewichtigen Frühgeborenen (VLBW)

Ansprechpartner:

PD Dr. Marc Reismann

Leitung des Fachbereiches kinderchirurgische Forschung

PD Dr. Marc Reismann

Aktuelle Publikationen der Kinderchirurgie

Operative Volume of Newborn Surgery in German University Hospitals: High Volume Versus Low Volume Centers. Adequate patient volume is essential for the maintenance of quality, meaningful research, and training of the next generation of pediatric surgeons. The role of university hospitals is to fulfill these tasks at the highest possible level. Due to decentralization of pediatric surgical care during the last decades, there is a trend toward reduction of operative caseloads. The aim of this study was to assess the operative volume of the most relevant congenital malformations at German academic pediatric surgical institutions over the past years.

Martin Lacher , Winfried Barthlen , Felicitas Eckoldt , Guido Fitze , Jörg Fuchs , Stuart Hosie , Martin M. Kaiser , Thomas Meyer , Oliver J. Muensterer  , Konrad Reinshagen , Karin Rothe , Guido Seitz , Gerhard Stuhldreier , Ralf-Bodo Troebs , Benno Ure , Dietrich von Schweinitz , Lucas Wessel , Lutz Wünsch , Udo Rolle 
A concise pathophysiological model of acute appendicitis against the background of the COVID-19 pandemic One of the most common clinical pictures has become the focus of attention during the COVID-19 pandemic: acute appendicitis with the associated diagnostics and therapy. The aim of the work is to show inconsistencies with regard to epidemiology, pathophysiology and therapy against the background of the pandemic with special attention to the conditions for children and to explain the pathophysiological processes that are likely to underlie the disease based on scientifically plausible models.

M. Reismann
Aktuelle Behandlungsstrategien der Ösophagusatresie Die Ösophagusatresie (ÖA) ist mit einer Inzidenz von 1 : 3000 bis 1 : 4000 Neugeborenen eine seltene, angeborene Erkrankung. Die Therapie beinhaltet obligatorisch die operative Korrektur. Behandlungskonzepte sind abhängig von der Variabilität der ösophagotrachealen Fistelmöglichkeiten, der variablen Distanz der Ösophagussegmente und der prognostischen Relevanz assoziierter Fehlbildungen.

K Rothe
The application of artificial intelligence methods to gene expression data for differentiation of uncomplicated and complicated appendicitis in children and adolescents - a proof of concept study Genome wide gene expression analysis has revealed hints for independent immunological pathways underlying the pathophysiologies of phlegmonous (PA) and gangrenous appendicitis (GA). Methods of artificial intelligence (AI) have successfully been applied to routine laboratory and sonographic parameters for differentiation of the inflammatory manifestations. In this study we aimed to apply AI methods to gene expression data to provide evidence for feasibility.

J Reismann, N Kiss, M Reismann
Use of gene expression profiling to identify candidate genes for pretherapeutic patient classification in acute appendicitis Phlegmonous and gangrenous appendicitis represent independent pathophysiological entities with different clinical courses ranging from spontaneous resolution to septic disease. However, reliable predictive methods for these clinical phenotypes have not yet been established.

N Kiss , M Minderjahn , J Reismann , J Svensson, T Wester, K Hauptmann , M Schad , J Kallarackal, H von Bernuth, M Reismann
Surgical Practice in Girls with Congenital Adrenal Hyperplasia: An International Registry Study. In this article international trends in surgical practice in girls with congenital adrenal hyperplasia (CAH) are evaluated. All cases that had been classified in the I-CAH/I-DSD registry as 46,XX CAH and who were born prior to 2017 were identified. Centers were approached to obtain information on surgical decision making.

Hebenstreit D, Ahmed S, Krone N, Krall C, Bryce J, Alvi S, Ortolano R, Lima M, Birkebaek N, Bonfig W, Claahsen van der Grinten H, Costa E, Poyrazoglu S, de Vries L, Flück C, Guran T, Bugrul F, Güven A, Iotova V, Koehler B, Schröder J.-T., Konrad D, Gevers E, Krone R, Milenkovic T, Vieites A, Ross R, Tadokoro Cuccaro R, Hughes I, Acerini C, Springer A
Diagnosis and classification of pediatric acute appendicitis by artificial intelligence methods: An investigator-independent approach. Acute appendicitis is one of the major causes for emergency surgery in childhood and adolescence. Appendectomy is still the therapy of choice, but conservative strategies are increasingly being studied for uncomplicated inflammation.

Reismann J, et al. PLoS One. 2019.
Sonographic differentiation of complicated from uncomplicated appendicitis This study aims to differentiate acute uncomplicated and complicated appendicitis, by investigating the correlation between sonographic findings and histological results in different types of paediatric appendicitis.

Rawolle T, Reismann M, Minderjahn MI, Bassir C, Hauptmann K, Rothe K, Reismann J
Eosinophilia in pediatric uncomplicated appendicitis is a time stable pattern. We have recently shown that uncomplicated phlegmonous appendicitis is characterized by independent inflammatory patterns based on significant eosinophilia in children aged 7-17 years. However, clinical decision-making based on inflammatory values is not easy, especially due to the dynamics of inflammation over time. The present study was performed to evaluate the basic distinguishability of the inflammatory entities by laboratory values over time based on an extended patient number with children aged 0-17 years.

Reismann J, Schädlich D, Minderjahn MI, Rothe K, Reismann M
Phlegmonous appendicitis in children is characterized by eosinophilia in white blood cell counts. Phlegmonous and complicated appendicitis represent independent entities depending on hereditary immunological mechanisms. However, clinically there are no means to distinguish uncomplicated phlegmonous from complicated appendicitis. The ability to distinguish these two forms of appendicitis is relevant as current attempts are to treat both forms of the disease differently. The aim of the present study was to investigate differences in white blood cell counts (WBCs) in these conditions to identify areas of interest for future molecular studies.

Minderjahn MI, Schädlich D, Radtke J, Rothe K, Reismann M
Obstruction of peritoneal dialysis catheter is associated with catheter type and independent of omentectomy: A comparative data analysis from a transplant surgical and a pediatric surgical department. Peritoneal dialysis (PD) catheter occlusion is a common complication with up to 36% of catheter obstructions described in the literature. We present a comparison of complications and outcome after implantation of PD catheters in a transplant surgical and a pediatric surgical department.

Josephine Radtke, Raphael Schild, Marc Reismann, Robert-Richard Ridwelski, Caroline Kempf, Bjoern Nashan, Karin Rothe, Martina Koch
The Effect of Wound Dressings on a Bio-Engineered Human Dermo-Epidermal Skin Substitute in a Rat Model. Autologous bio-engineered dermo-epidermal skin substitutes are a promising treatment for large skin defects such as burns. For their successful clinical application, the graft dressing must protect and support the keratinocyte layer and, in many cases, possess antimicrobial properties. However, silver in many antimicrobial dressings may inhibit keratinocyte growth and differentiation. The purpose of our study was to evaluate the effect of various wound dressings on the healing of a human hydrogel-based dermo-epidermal skin substitute in preparation for the first-in-human clinical trials.

Hüging M, Biedermann T, Sobrio M, Meyer S, Böttcher-Haberzeth S, Manuel E, Horst M, Hynes S, Reichmann E, Schiestl C, Hartmann-Fritsch F.
Pulmonary outcome of esophageal atresia patients and its potential causes in early childhood. The aim of this study was to illustrate the pulmonary long term outcome of patients with repaired esophageal atresia and to further examine causes and correlations that might have led to this outcome.

Dittrich R, Stock P, Rothe K, Degenhardt P
Incidence of BK polyomavirus infection after kidney transplantation is independent of type of immunosuppressive therapy. BK polyomavirus (BKV) infection and BKV nephropathy (BKVN) are risk factors for allograft function and survival.

Josephine Radtke, Nina Dietze, Lutz Fischer, Eike‐Gert Achilles, Jun Li , Silke Scheidat, Friedrich Thaiss, Bjoern Nashan, Martina Koch
Improvements in Incontinence with Self-Management in Patients with Anorectal Malformations There are limited data available in children with anorectal malformation (ARM) regarding the use of transanal colonic irrigation delivered with the Peristeen system. To our knowledge no study has combined the element of controlled evacuation with self-management strategies. Our center began offering this management regimen 5 years ago to patients suffering from fecal incontinence.

Märzheuser S, Karsten K, Rothe K
Surgical complications after peritoneal dialysis catheter implantation depend on children's weight Surgical complications are estimated to be as high as 30%-40% during the first 8 weeks after implantation of peritoneal dialysis (PD) catheters.

Radtke J, Lemke , Kemper M, Nashan B, Koch M
TLR4 preconditioning is associated with low success of OK-432 treatment for lymphatic malformations in children We have recently shown that the relative TLR4 expression on monocytes of low responding pediatric patients after OK-432 treatment is significantly reduced after stimulation with lipopolysaccharide (LPS) compared with high responding children. The aim of this study was to perform further analysis to explain this observation.

Reismann M, Ghaffarpour N, Luvall E, Jirmo A, Radtke J, Claesson G, Wester T
Voiding Cystourethrography in the Diagnosis of Anorectal Malformations. In a newborn with an anorectal malformation (ARM), it is vital to determine the anatomy of the underlying defect. After a colostomy has been created, distal colostography (DCG) is currently the chosen modality for the detection of fistulas. The role of voiding cystourethrography (VCU) is unexplored.

Karsten K, Rothe K, Märzheuser S